A U.S. drone fired a missile insie Pakistan's North Waziristan tribal region on Monday, killing at least four people, intelligence officials and residents said.
The latest attack took place near Mir Ali, the second major town of North Waziristan.
The blast was so huge that it could be heard as far as Miranshah, the main town of the sparsely-populated region, which is about 24 km (15 miles) from Mir Ali.
Akhtar Rasool, a resident of Mir Ali, said the missile appeared to have struck a vehicle.
"The vehicles is in flames and we can see smoke rising from the scene," he told Reuters by telephone.
An intelligence official said that the death toll may rise.
Pakistan officially objects to the U.S. missile strikes saying they are a violation of its sovereignty and cause civilian casualties, which bolster support for armed groups.
But local media reports have suggested that the strike that killed Taliban leader Mehsud was carried out with Islamabad's coordination.
Facing surging resistance in neighbouring Afghanistan, the United States stepped up its missile strikes in Pakistan last year, killing hundreds.
Güncelleme Tarihi: 14 Eylül 2009, 13:28